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This is a very good question that I wish was asked more. Obviously stick to the basics of SEO but as for content I like to make my index pages with 100% unique copy. I set the main word keyword ratio to around 4% without going over 20 words on around a 700 WPP words per page.

Don't go over 50 links on your front page. Put at least 4 images and name them to the subject that you are focusing on. ex: widgets.jpg widgets.gif blue-widgets.jpg.

Try to limit the size of your site template to the raw content. I have built sites with 50/50 where as you only have 50% of unique content with the remainder being consistant throughout.

I have found that going with a 80% unique and 20% template content works. Yahoo does not like template copy as much so that will help with Yahoo also.

Build your site at least 15 pages deep. Always try to tighten up your file extensions. eg: mysite.com/page1.html

Follow all the basics and you will be fine.